{"id":4555,"date":"2021-12-22T08:04:46","date_gmt":"2021-12-22T08:04:46","guid":{"rendered":"https:\/\/bioingenieria.zeus.umh.es\/grupo-toxicologia-y-salud-medioambiental\/"},"modified":"2022-12-09T19:11:25","modified_gmt":"2022-12-09T19:11:25","slug":"grupo-toxicologia-y-salud-medioambiental","status":"publish","type":"page","link":"https:\/\/bioingenieria.umh.es\/en\/unidad-de-toxicologia\/grupo-toxicologia-y-salud-medioambiental\/","title":{"rendered":"Grupo Toxicolog\u00eda y Salud Medioambiental"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” admin_label=”Secci\u00f3n” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_fullwidth_header title=”Toxicolog\u00eda y Salud Medioambiental” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”4.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”section” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.16″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”][et_pb_tab title=”Informaci\u00f3n” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n
Responsable<\/strong><\/td>\nEugenio Vilanova Gisbert<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESUMEN DE LA INVESTIGACI\u00d3N<\/strong><\/h4>\n

El grupo est\u00e1 centrado en el estudio de mecanismos moleculares de toxicidad e identificaci\u00f3n de rutas de efecto adverso de diversos xenobi\u00f3ticos, desde nanopart\u00edculas hasta compuestos organofosforados como plaguicidas, retardadores de llama. El grupo tambi\u00e9n tiene una actividad en toxicolog\u00eda reguladora y en elaboraci\u00f3n de informes de evaluaci\u00f3n del riesgo de exposici\u00f3n a diversas sustancias qu\u00edmicas para la salud humana y el medio ambiente.<\/p>\n

L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/h4>\n

 <\/p>\n

L\u00ednea 1: Estudio de los mecanismos moleculares de toxicidad de diversos tipos de xenobi\u00f3ticos<\/strong><\/h4>\n

Se estudian las alteraciones celulares y moleculares causadas por xenobi\u00f3ticos que supongan eventos clave en el desencadenamiento de respuestas t\u00f3xicas de los sistemas diana de estos xenobi\u00f3ticos. Se emplean t\u00e9cnicas de biolog\u00eda molecular, bioqu\u00edmica y \u00f3micas.<\/p>\n

\"1\"<\/p>\n

Nanopart\u00edculas de \u00f3xido de titanio en el interior de una c\u00e9lula de glioblastoma humano T98G<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 2: Desarrollo de m\u00e9todos alternativos a la experimentaci\u00f3n animal para la evaluaci\u00f3n de neurotoxicidad y toxicidad al desarrollo embrionario de xenobi\u00f3ticos<\/strong><\/h4>\n

Se identifican marcadores moleculares de efecto de exposici\u00f3n a xenobi\u00f3ticos en cultivos celulares de c\u00e9lulas nerviosas y c\u00e9lulas madre embrionarias. Estos biomarcadores se utilizan para desarrollar m\u00e9todos que predigan los efectos adversos de xenobi\u00f3ticos.<\/p>\n

\"2\"<\/p>\n

Esquema de un procedimiento alternativo a la experimentaci\u00f3n animal para predecir el potencial embriot\u00f3xico de xenobi\u00f3ticos. Tomado de Romero et al., Toxicology Letters 2015; 238:60-69<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 3:\u00a0Identificaci\u00f3n de nuevas dianas moleculares de toxicidad de organofosforados<\/strong><\/h4>\n

Identificaci\u00f3n de carboxilesterasas susceptibles de ser nuevas dianas de neurot\u00f3xicidad de compuestos organofosforados en aves y mam\u00edferos. Se utilizan t\u00e9cnicas de prote\u00f3mica y bioqu\u00edmicas.<\/span><\/strong><\/p>\n

\"3\"<\/p>\n

Esquema del procedimiento usado en la identificaci\u00f3n de dianas de neurotoxicidad en aves.<\/span><\/strong>\u00a0<\/em><\/p>\n

 <\/p>\n

L\u00ednea 4: Mecanismos moleculares de interacci\u00f3n de sustratos e inhibidores con colinesterasas<\/strong><\/h4>\n

Se estudian los mecanismos moleculares de la interacci\u00f3n de diversos sustratos e inhibidores con colinesterasas, en especial con la acetilcolinesterasa enzima encargada de regular el neurotransmisor acetilcolina.
\n\"4\"<\/p>\n

Esquema del ensayo de reactivaci\u00f3n espontanea de las actividades de la acetilcolinesterasa tras inhibici\u00f3n con paraoxon<\/em><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Miembros” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
Nombre<\/strong><\/td>\nPuesto<\/strong><\/td>\nCorreo<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Miguel \u00c1ngel Sogorb S\u00e1nchez<\/td>\nCatedr\u00e1tico de Universidad<\/td>\nmsogorb@umh.es<\/a><\/td>\n0000-0002-1594-8940<\/td>\n<\/tr>\n
Ana M Peir\u00f3 Peir\u00f3<\/td>\nProfesora Titular de Universidad<\/td>\napeiro@umh.es<\/a><\/td>\n0000-0002-2385-3749<\/td>\n<\/tr>\n
Eugenio Vilanova Gisbert<\/td>\nCatedr\u00e1tico Em\u00e9rito<\/td>\nevilanova@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Roberto Antonio Ruiz Cruz<\/td>\nPersonal Investigador<\/td>\nrruiz@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Jorge Est\u00e9vez Dom\u00e8nech<\/td>\nProfesor Titular de Universidad<\/td>\njorge.estevez@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Carmen Estevan Mart\u00ednez<\/td>\nColaboradora<\/td>\ncarmen.estevanmartinez@echa.europa.eu<\/span><\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_tab][et_pb_tab title=”Publicaciones” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

C. Estevan, E Vilanova, M.A. Sogorb<\/span>
<\/strong><\/a>Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19<\/a><\/strong>
Arch Toxicol 96(1):105-119 (2022)<\/span><\/p>\n

E Fuster, H Candela, J Est\u00e9vez, E Vilanova, M.A. Sogorb<\/span>
<\/strong><\/a>A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation.<\/a><\/strong>
Int J Mol Sci. 23(4):2267 (2022)<\/span>\u00a0<\/p>\n

\n

P. Ballester, A.L. Richdale, E.K. Baker, A.M. Peiro
Sleep in autism: a biomolecular approach to aetiology and treatment<\/strong><\/a>
Sleep Medicine Reviews (2020)<\/p>\n

M. Benjeddou, A.M. Peir\u00f3
Pharmacogenomics and prescription opioid use<\/strong><\/a>
Pharmacogenomics (2020)<\/p>\n

M.\u00c1. Pena, J. Muriel, M. Saiz-Rodr\u00edguez, A.M. Borobia, F. Abad-Santos, J. Fr\u00edas, A.M. Peir\u00f3
Effect of cytochrome P450 and ABCB1 polymorphisms on Imatinib pharmacokinetics after single-dose administration to healthy subjects<\/strong><\/a>
Clinical Drug Investigation (2020)<\/p>\n

E. Fuster, H. Candela, J. Est\u00e9vez, E. Vilanova, M.A. Sogorb
Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells.<\/strong><\/a>
International Journal of Molecular Sciences 22, 2084 (2021)<\/p>\n

E. Fuster, H. Candela, J. Est\u00e9vez, A.J. Arias, E. Vilanova, M.A. Sogorb
Effects of silver nanoparticles on T98G human glioblastoma cells.<\/strong><\/a>
Toxicology Applied Pharmacolgy, 404:115178 (2020)<\/p>\n

M.A. Sogorb, J. Est\u00e9vez, E. Vilanova
Case study: Is bisphenol S safer than bisphenol A in thermal papers?<\/strong><\/a>
Archives of Toxicology 93:1835-1852 (2019)<\/p>\n

M. Gonz\u00e1lez-Gonz\u00e1lez, J. Est\u00e9vez, E. Del R\u00edo, E. Vilanova, M.A. Sogorb
Hydrolyzing activities of phenyl valerate sensitive to organophosphorus compounds paraoxon and mipafox in human neuroblastoma SH-SY5Y cells.<\/strong><\/a>
Toxicology 406-407:123-128 (2018)<\/p>\n

J. Est\u00e9vez, M. Benabent, V. Selva, I. Mangas, M.A. Sogorb, E. Del Rio, E. Vilanova
Cholinesterase and phenyl valerate-esterase activities sensitive to organophosphorus compounds in membranes of chicken brain.<\/strong><\/a>
Toxicology 410:73-82 (2018).<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Proyectos” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

Sesgos de g\u00e9nero en la medicina del dolor: farmacogen\u00e9tica, farmacocin\u00e9tica y metabol\u00f3mica. Funding agency: Proyectos de Investigaci\u00f3n Clinica Independiente (ICI 2020). Instituto de Salud Carlos III, ISCIII. Duration: 2020-2024.
\nPI: Ana Peir\u00f3<\/em><\/p>\n

\n

Deprescripci\u00f3n en pacientes con dependencia a opioides. Funding agency: Programa Difunde. Universidad Miguel Hern\u00e1ndez. Duration: 2020-2021.
\nPI: Ana Peir\u00f3<\/em><\/p>\n

\n

Marcadores farmacogen\u00e9ticos en la medicina del dolor. Funding agency: Fundaci\u00f3n Espa\u00f1ola del Dolor. Duration: 2019-2020.
\nPI: Ana Peir\u00f3<\/em><\/p>\n

\n

Hacia un nuevo paradigma en la identificaci\u00f3n de peligros y evaluaci\u00f3n de la seguridad y el riesgo de neurotoxicidad asociado la exposici\u00f3n a nanomateriales con aplicaciones biotecnol\u00f3gicas. Funding agency: Fundaci\u00f3n Ram\u00f3n Areces. Duration: 2017-2019.
\nPI: Miguel A. Sogorb<\/em><\/p>\n

\n

Farmacogen\u00e9tica aplicada a nuevos medicamentos opioides para el dolor cr\u00f3nico. Funding agency: Universidad Miguel Hern\u00e1ndez. Duration: 2017-2018.
\nPI: Ana Peir\u00f3<\/em>[\/et_pb_tab][et_pb_tab title=”Actividades” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n
Nombre<\/th>\nActividades<\/th>\n<\/tr>\n
Eugenio Vilanova<\/td>\nHonorary Member de EUROTOX<\/td>\n<\/tr>\n
Miguel \u00c1ngel Sogorb<\/td>\nMiembro del Comit\u00e9 de Evaluaci\u00f3n de Riesgos de la Agencia Europea de las Sustancias Qu\u00edmicas<\/td>\n<\/tr>\n
Ana Peir\u00f3<\/td>\nMiembro Comit\u00e9 \u00c9tico Investigaci\u00f3n Cl\u00ednica. Miembro del comi\u00b4te Cient\u00edfico de \u00abDimensiones en la humanizaci\u00f3n de la persona con dolor cr\u00f3nico\u00bb. Miembro Comit\u00e9 Bio\u00e9tica Asistencial. Miembro Comit\u00e9 de Medicamentos de Alto impacto sanitario-Grupo-hemato-Oncolog\u00eda. Miembro de la Comisi\u00f3n de Investigaci\u00f3n.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Los miembros del grupo han colaborado activamente con el Ministerio de Sanidad en la elaboraci\u00f3n de dosieres de registro de biocidas[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Secci\u00f3n” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_fullwidth_header title=”Toxicology and Environmental Health Group” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”4.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.17.4″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”][et_pb_tab title=”Information” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n
Responsible<\/strong><\/td>\nEugenio Vilanova Gisbert<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESEARCH SUMMARY<\/strong><\/h4>\n

The group is focused on the study of molecular mechanisms of toxicity and identification of adverse effect pathways of various xenobiotics, from nanoparticles to organophosphorus compounds such as pesticides, flame retardants. The group is also active in regulatory toxicology and in the preparation of risk assessment reports on exposure to various chemicals for human health and the environment.\u00a0<\/p>\n

RESEARCH LINES<\/strong><\/h4>\n

 <\/p>\n

Line 1:\u00a0Study of the molecular mechanisms of toxicity of various types of xenobiotics<\/strong><\/h4>\n

Cellular and molecular alterations caused by xenobiotics that represent key events in the triggering of toxic responses of the target systems of these xenobiotics are studied. Molecular biology, biochemical and omics techniques are used.<\/p>\n

\"1\"<\/p>\n

Titanium oxide nanoparticles inside a T98G human glioblastoma cell.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

Line 2:\u00a0Development of alternative methods to animal experimentation for the evaluation of neurotoxicity and embryonic developmental toxicity of xenobiotics.<\/strong><\/h4>\n

Molecular markers of xenobiotic exposure effects are identified in cell cultures of nerve cells and embryonic stem cells. These biomarkers are used to develop methods to predict the adverse effects of xenobiotics.<\/p>\n

\"2\"<\/p>\n

Schematic of an alternative procedure to animal experimentation to predict the embryotoxic potential of xenobiotics. Taken from Romero et al., Toxicology Letters 2015; 238:60-69.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 3:\u00a0Identification of novel molecular targets of organophosphate toxicity<\/strong><\/h4>\n

Identification of carboxylesterases susceptible to be new targets of neurotoxicity of organophosphorus compounds in birds and mammals. Proteomic and biochemical techniques are used.<\/span><\/strong><\/p>\n

\"3\"<\/p>\n

Schematic of the procedure used in the identification of neurotoxicity targets in birds.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

Line 4:\u00a0Molecular mechanisms of interaction of substrates and inhibitors with cholinesterases<\/strong><\/h4>\n

The molecular mechanisms of the interaction of various substrates and inhibitors with cholinesterases are studied, especially with acetylcholinesterase, an enzyme responsible for regulating the neurotransmitter acetylcholine.<\/p>\n

\"4\"<\/p>\n

Schematic of the spontaneous reactivation assay of acetylcholinesterase activities after inhibition with paraoxon.<\/em><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Members” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
Name<\/strong><\/td>\nPosition<\/strong><\/td>\ne-mail<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Miguel \u00c1ngel Sogorb S\u00e1nchez<\/td>\nFull Professor<\/td>\nmsogorb@umh.es<\/a><\/td>\n0000-0002-1594-8940<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/a><\/td>\n<\/td>\n<\/tr>\n
Eugenio Vilanova Gisbert<\/td>\nEmeritus Professor<\/td>\nevilanova@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Jorge Est\u00e9vez Dom\u00e8nech<\/td>\nAssociate Professor<\/td>\n\u00a0jorge.estevez@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0Roberto Antonio Ruiz Cruz<\/td>\nResearch Staff<\/td>\n\u00a0<\/a>rruiz@umh.es<\/a><\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Carmen Estevan Mart\u00ednez<\/td>\nPh.D. Assistant Lecturer<\/td>\ncarmen.estevanmartinez@echa.europa.eu<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_tab][et_pb_tab title=”Publications” _builder_version=”4.17.4″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

M. Luconi, M.A. Sogorb, U.R. Markert, E. Benfenati, T. May, S. Wolbank, A. Roncaglioni, A. Schmidt, M. Straccia, S. Tait<\/span><\/p>\n

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto\u2013Placental Organ-on-Chip Platform. <\/a><\/strong><\/p>\n

Int. J. Environ. Res. Public Health 19, 15828 (2022).<\/span><\/p>\n

\n

C. Estevan, E Vilanova, M.A. Sogorb
Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19<\/a><\/strong>
Arch Toxicol 96(1):105-119 (2022).<\/p>\n

E Fuster, H Candela, J Est\u00e9vez, E Vilanova, M.A. Sogorb
A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation.<\/a><\/strong>
Int J Mol Sci. 23(4):2267 (2022).<\/p>\n

J. Est\u00e9vez, M. Terol, M.A. Sogorb, E. Vilanova.
Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity.<\/b><\/a>
Int J Mol Sci. 23(4):2267 (2022).<\/p>\n

E. Fuster, H. Candela, J. Est\u00e9vez, E. Vilanova, M.A. Sogorb
Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells.<\/strong><\/a>
International Journal of Molecular Sciences 22, 2084 (2021).<\/p>\n

E. Fuster, H. Candela, J. Est\u00e9vez, A.J. Arias, E. Vilanova, M.A. Sogorb
Effects of silver nanoparticles on T98G human glioblastoma cells.<\/strong><\/a>
Toxicology Applied Pharmacolgy, 404:115178 (2020).<\/p>\n

M.A. Sogorb, J. Est\u00e9vez, E. Vilanova
Case study: Is bisphenol S safer than bisphenol A in thermal papers?<\/strong><\/a>
Archives of Toxicology 93:1835-1852 (2019).<\/p>\n

M. Faria, I. Fuertes, E. Prats, JL. Abad, F. Padr\u00f3s, C. G\u00f3mez-Canela, J. Casas, J. Est\u00e9vez, E. Vilanova, B. Pi\u00f1a, D. Rald\u00faa.\u00a0 <\/span>
Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish.<\/b><\/a>\u00a0 <\/b><\/strong>
Scientific Reports 8(1):4844 (2018).<\/span><\/p>\n

M. Gonz\u00e1lez-Gonz\u00e1lez, J. Est\u00e9vez, E. Del R\u00edo, E. Vilanova, M.A. Sogorb
Hydrolyzing activities of phenyl valerate sensitive to organophosphorus compounds paraoxon and mipafox in human neuroblastoma SH-SY5Y cells.<\/strong><\/a>
Toxicology 406-407:123-128 (2018).<\/p>\n

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[\/et_pb_tab][et_pb_tab title=”Projects” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

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Hacia un nuevo paradigma en la identificaci\u00f3n de peligros y evaluaci\u00f3n de la seguridad y el riesgo de neurotoxicidad asociado la exposici\u00f3n a nanomateriales con aplicaciones biotecnol\u00f3gicas. Funding agency: Fundaci\u00f3n Ram\u00f3n Areces. Duration: 2017-2019.<\/p>\n

PI: Miguel A. Sogorb<\/em><\/p>\n

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[\/et_pb_tab][et_pb_tab title=”Activities” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n
Name<\/th>\nActivities<\/th>\n<\/tr>\n
Eugenio Vilanova<\/td>\nHonorary Member de EUROTOX<\/td>\n<\/tr>\n
Miguel \u00c1ngel Sogorb<\/td>\nMember of the Risk Assessment Committee of the European Chemicals Agency.<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

The members of the group have actively collaborated with the Ministry of Health in the preparation of biocide registration dossiers.<\/p>\n

[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][:es _i=”0″ _address=”4.0.0.0″ \/][:en _i=”1″ _address=”4.0.0.1″ \/][: _i=”2″ _address=”4.0.0.2″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Responsable Eugenio Vilanova Gisbert   RESUMEN DE LA INVESTIGACI\u00d3N El grupo est\u00e1 centrado en el estudio de mecanismos moleculares de toxicidad e identificaci\u00f3n de rutas de efecto adverso de diversos xenobi\u00f3ticos, desde nanopart\u00edculas hasta compuestos organofosforados como plaguicidas, retardadores de llama. El grupo tambi\u00e9n tiene una actividad en toxicolog\u00eda reguladora y en elaboraci\u00f3n de informes […]<\/p>\n","protected":false},"author":17014,"featured_media":0,"parent":4267,"menu_order":74,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4555"}],"collection":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/users\/17014"}],"replies":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/comments?post=4555"}],"version-history":[{"count":0,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4555\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4267"}],"wp:attachment":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/media?parent=4555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}