{"id":4564,"date":"2021-12-22T08:13:04","date_gmt":"2021-12-22T08:13:04","guid":{"rendered":"https:\/\/bioingenieria.zeus.umh.es\/grupo-de-toxicologia-y-riesgo-poblacional\/"},"modified":"2022-03-30T12:07:45","modified_gmt":"2022-03-30T12:07:45","slug":"grupo-de-toxicologia-y-riesgo-poblacional","status":"publish","type":"page","link":"https:\/\/bioingenieria.umh.es\/en\/unidad-de-toxicologia\/grupo-de-toxicologia-y-riesgo-poblacional\/","title":{"rendered":"Grupo de Toxicolog\u00eda y Riesgo Poblacional"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” admin_label=”Secci\u00f3n” _builder_version=”3.22″ disabled=”on”][et_pb_fullwidth_header title=”Toxicolog\u00eda y Riesgo Poblacional” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”3.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”section” _builder_version=”3.22″ disabled=”on”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.2.2″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid”][et_pb_tab title=”Informaci\u00f3n” _builder_version=”4.2.2″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n\n\n\n
Responsable<\/strong><\/td>\nDr. Javier Esteban Mozo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESUMEN DE LA INVESTIGACI\u00d3N<\/strong><\/h4>\n

El grupo de investigaci\u00f3n tiene como objetivo central el estudio de mecanismos de toxicidad y factores modificadores, tanto gen\u00e9ticos como ambientales, que afectan a la respuesta de las poblaciones expuestas a contaminantes ambientales, tales como compuestos org\u00e1nicos persistentes y alteradores endocrinos, f\u00e1rmacos y sustancias adictivas.<\/p>\n

\"tox<\/p>\n

Imagen tomada de Suylen Galb\u00e1n Vel\u00e1zquez et al. (2021). Environmental Research 195:110764. https:\/\/doi.org\/10.1016\/j.envres.2021.110764<\/a><\/em><\/p>\n

 <\/p>\n

L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/h4>\n

 <\/p>\n

L\u00ednea 1:\u00a0Evaluaci\u00f3n de la respuesta de biomarcadores en muestras biol\u00f3gicas de poblaciones humanas expuestas a contaminantes ambientales<\/strong><\/h4>\n

Las poblaciones humanas est\u00e1n expuestas a una gran cantidad de sustancias qu\u00edmicas en entornos laborales y ambientales. Los contaminantes ambientales que persisten en el medioambiente, bien por su continua emisi\u00f3n o por su lenta biodegradaci\u00f3n, se distribuyen ubicuamente en forma de mezclas complejas, se acumulan en los organismos vivos y causan toxicidad.<\/span><\/p>\n

La b\u00fasqueda de indicadores tempranos es \u00fatil para detectar el desarrollo de estados patol\u00f3gicos que constituyen graves problemas de salud p\u00fablica, tales como obesidad, diabetes, enfermedades cardiovasculares, s\u00edndrome metab\u00f3lico, alteraciones del sistema inmunol\u00f3gico, c\u00e1ncer, as\u00ed como trastornos reproductivos y del desarrollo derivadas de la exposici\u00f3n a sustancias qu\u00edmicas.<\/span><\/p>\n

L\u00ednea 2:\u00a0Evaluaci\u00f3n de biomarcadores moleculares en pacientes tratados con psicof\u00e1rmacos que predisponen al s\u00edndrome metab\u00f3lico<\/strong><\/h4>\n

La presencia de m\u00faltiples factores que intervienen en la patogenia, as\u00ed como predisposici\u00f3n gen\u00e9tica y h\u00e1bitos de vida, dificultan el esclarecimiento de mecanismos que determinan el curso de alteraciones endocrinas como el s\u00edndrome metab\u00f3lico en poblaci\u00f3n general.
\nPor ello, el estudio en pacientes bajo control m\u00e9dico que reciben un tratamiento que predispone, como efecto secundario, al desarrollo del s\u00edndrome metab\u00f3lico, permite obtener informaci\u00f3n acerca de biomarcadores ligados a mecanismos de acci\u00f3n, tales como elementos clave del sistema retinoide, y otros ligados a factores de susceptibilidad individual, como la paraoxonasa. Se propone que la determinaci\u00f3n de tales biomarcadores facilitar\u00eda la identificaci\u00f3n de grupos de riesgo.[\/et_pb_tab][et_pb_tab title=”Miembros” _builder_version=”3.0.48″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n\n\n\n\n\n\n
Name<\/strong><\/td>\nPosition<\/strong><\/td>\ne-mail<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Dr. Javier Esteban Mozo<\/td>\nProfesor Contratado Doctor<\/td>\njesteban@umh.es<\/a><\/td>\n0000-0003-3760-8223<\/td>\n<\/tr>\n
Dr. Jose Barril Antu\u00f1a<\/td>\nProfesor Titular de Universidad<\/td>\njose.barril@umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n
Dra. M\u00aa de la Cruz Pell\u00edn Mira<\/td>\nProfesora Titular de Universidad<\/td>\nmc.pellin@umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_tab][et_pb_tab title=”Publicaciones” _builder_version=”3.0.48″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n

J. Esteban, I. S\u00e1nchez-P\u00e9rez, G. Hamscher, H. M Miettinen, M. Korkalainen, M. Viluksela, R. Pohjanvirta, H. H\u00e5kansson
\nRole of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice<\/a><\/strong>
\nReproductive Toxicology (2021).<\/p>\n

S. Galb\u00e1n-Vel\u00e1zquez, J. Esteban, G. \u00c7akmak, F. Artacho-Cord\u00f3n, J. Le\u00f3n, J. Barril, F. Vela-Soria, P. Martin-Olmedo, M. F Fernandez, M. C. Pell\u00edn, J. P Arrebola
\nAssociations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment<\/a><\/strong>
\nEnvironmental Research (2021).<\/p>\n

J. Esteban, M. Serrano-Maci\u00e1, I. S\u00e1nchez-P\u00e9rez, P. Alonso-Magdalena, M. C. Pell\u00edn, M. Garc\u00eda-Ar\u00e9valo, \u00c1. Nadal, J. Barril
\nIn utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring<\/a><\/strong>
\nFood and Chemical Toxicology (2019).<\/p>\n

S. Mahiout, J. Lind\u00e9n, J. Esteban, I. S\u00e1nchez-P\u00e9rez, S. Sankari, L. Pettersson, H. H\u00e5kansson, R. Pohjanvirta
\nToxicological characterisation of two novel selective aryl hydrocarbon receptor modulators in Sprague-Dawley rats<\/a><\/strong>
\nToxicology and Applied Pharmacology (2017).<\/p>\n

S. B. Sholts, J. Esteban, M. Herlin, M. Viluksela, H. H\u00e5kansson
\nCraniofacial form is altered by chronic adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Han\/Wistar and Long-Evans rats with different aryl hydrocarbon receptor (AhR) structures<\/a><\/strong>
\nToxicology Reports (2015).<\/p>\n

J. Esteban, L. E. Elabbas, D. Borg, M. Herlin, A. \u00c5kesson, X. Barber, G. Hamscher, H. Nau, W. J. Bowers, J. S. N., M. Viluksela, H. H\u00e5kanssona
\nGestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring<\/a><\/strong>
\nToxicology Letters (2014).<\/p>\n

L. E. Elabbas, J. Esteban, X. Barber, G. Hamscher, H. Nau, W. J. Bowers, J. S. Nakai, M. Herlin, A. \u00c5kesson, M. Viluksela, D. Borg, H. H\u00e5kansson
\nIn utero and lactational exposure to a mixture of environmental contaminants detected in canadian arctic human populations alters retinoid levels in rat offspring with low margins of exposure<\/a><\/strong>
\nJournal of Toxicology and Environmental Health – Part A: Current Issues (2014).<\/p>\n

M. Viluksela, P. Heikkinen, L. T. M. van der Ven, F. Rendel, R. Roos, J. Esteban,M. Korkalainen,S. Lensu,H. M. Miettinen, K. Savolainen, S. Sankari, H. Lilienthal, A. Adamsson, J. Toppari, M. Herlin, M. Finnil\u00e4, J. Tuukkanen, H. A. Leslie, T. Hamers, G. Hamscher, L. Al-Anati, U. Stenius, K. Dervola, I. Bogen, F. Fonnum, P. L. Andersson, D. Schrenk, K. Halldin, H. H\u00e5kansson
\nToxicological profile of ultrapure 2,2\u2032,3,4,4\u2032,5,5\u2032- heptachlorbiphenyl (PCB 180) in adult rats<\/a><\/strong>
\nPLoS ONE (2014).<\/p>\n

C. L\u00f3pez-Granero, D. Cardona, E. Gim\u00e9nez, R. Lozano, J. Barril, M. Aschner, F. S\u00e1nchez-Santed, F. Ca\u00f1adas
\nComparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression<\/a><\/strong>
\nNeurotoxicology (2014).<\/p>\n

R. Pohjanvirta, I. Karppinen, S. Galb\u00e1n-Vel\u00e1zquez, J. Esteban, H. H\u00e5kansson, S. Sankari, J. Lind\u00e9n
\nEffects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats<\/a><\/strong>
\nThe Journal of Nutritional Biochemistry, Volume 95 (2021).<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Proyectos” _builder_version=”3.0.48″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n

Contrato para la realizaci\u00f3n del trabajo “Evaluaci\u00f3n de la respuesta del marcador de inflamaci\u00f3n RBP4 en suero de humanos expuestos a contaminantes ambientales que causan estr\u00e9s oxidativo. Funding agency: FIBAO1.20T. Duration: 03\/12\/2020 – 03\/2\/2021.
PI: Javier Esteban<\/em><\/p>\n

\n

Raising the awareness of healthy food and healthy eating among children. Funding agency: European Commission 2011-1-TR1-LEO04-27384. Duration: 01\/08\/2011 – 31\/07\/2013.
PI: Javier Esteban<\/em><\/p>\n

\n

Disruption of the retinoid system by non-dioxin-like polychlorinated byphenyls present in food. Funding agency: Proyectos BANCAJA-UMH. Duration: 01\/01\/2009 – 31\/12\/2010.
PI: Javier Esteban<\/em><\/p>\n

\n

Efectos neurotoxicos a largo plazo de la exposicion a compuestos organofosforados: Implicacion de nuevas variantes de las enzimas ache y otras carboxilesterasas. Funding agency: Becas y ayudas para el fomento de la investigacion cientifica y el desarrollo tecnologico e\\gv07\/158. Duration: 01\/01\/2007 – 31\/12\/2008.
PI: Jos\u00e9 Ram\u00f3n Barril<\/em><\/p>\n

\n

Influencia de la comedicacion de antirretrovirales y psicofarmacos en los niveles plasmaticos. Funding agency: Conselleria de sanidad. Duration: 18\/02\/2005 – 31\/12\/2005.
PI: Javier Esteban<\/em><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Actividades” _builder_version=”3.0.48″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]T\u00edtulo del trabajo<\/strong>: Alteraci\u00f3n del sistema retinoide por exposici\u00f3n a xenobi\u00f3ticos
\nDentro del Programa<\/strong>: Doctorado en Bioingenier\u00eda (RD 1393\/2007)
\nTipo de proyecto<\/strong>: Tesis Doctoral
\nEntidad de realizaci\u00f3n<\/strong>: Universidad Miguel Hern\u00e1ndez
\nAlumno\/a<\/strong>: SANCHEZ PEREZ, ISMAEL
\nCalificaci\u00f3n obtenida<\/strong>: Sobresaliente Cum Laude
\nFecha de defensa<\/strong>: 22\/09\/2017<\/p>\n

T\u00edtulo del trabajo: <\/strong>Toxicity of brominated flame retardants with focus on retinoid system disturbances
\nDentro del Programa<\/strong> : Karolinska Institutet
\nTipo de proyecto<\/strong>: Tesis Doctoral
\nEntidad de realizaci\u00f3n<\/strong>: UNIVERSIDAD MIGUEL HERN\u00c1NDEZ DE ELCHE
\nAlumno\/a<\/strong>: Sabina Litens Karlsson
\nCalificaci\u00f3n obtenida<\/strong>: Sobresaliente Cum Laude
\nFecha de defensa<\/strong>: 08\/06\/2015<\/p>\n

Nombre de la exposici\u00f3n: <\/strong>Raising the awareness of healthy food and healthy eating among children
\nAutores\/as<\/strong>: Esteban, J.; Barril, J.; E. Garcia Garcia; Pell\u00edn, M.C.
\nForo donde se expone<\/strong>: HEALTHY FOOD \u2013 EUROPEAN COMMISSION
\nFecha de inicio<\/strong>: 01\/08\/2011
\nDisponible en<\/strong>: Alimentaci\u00f3n saludable para una vida sana<\/a>. ISBN 978-84-16024-02-5[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Secci\u00f3n” _builder_version=”3.22″][et_pb_fullwidth_header title=”Toxicology and Population Risk Group” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”3.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”section” _builder_version=”3.22″][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.2.2″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid”][et_pb_tab title=”Information” _builder_version=”4.2.2″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n\n\n\n
Responsible<\/strong><\/td>\nDr. Javier Esteban Mozo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESEARCH SUMMARY<\/strong><\/h4>\n

The main objective of the group is the study of mechanisms of toxicity and both genetic and environmental modifying factors, that affect the response of the populations exposed to environmental pollutants, such as persistent organic compounds and endocrine disruptors, drugs and addictive substances.<\/p>\n

\"tox<\/p>\n

Image taken from Suylen Galb\u00e1n Vel\u00e1zquez\u00a0et al. (2021). Environmental Research 195:110764. https:\/\/doi.org\/10.1016\/j.envres.2021.110764<\/a><\/em><\/p>\n

 <\/p>\n

RESEARCH LINES<\/strong><\/h4>\n

 <\/p>\n

Line 1:\u00a0Evaluation of biomarker response in biological samples from human populations exposed to environmental contaminants<\/strong><\/h4>\n

Human populations are exposed to a large number of chemicals in occupational and environmental settings. Environmental pollutants that persist in the environment, either by continuous emission or by slow biodegradation, are ubiquitously distributed in the form of complex mixtures, accumulate in living organisms and cause toxicity.<\/p>\n

The search for early indicators is useful for detecting the development of pathological states that constitute serious public health problems, such as obesity, diabetes, cardiovascular diseases, metabolic syndrome, immune system alterations, cancer, as well as reproductive and developmental disorders derived from exposure to chemical substances.\u00a0<\/p>\n

Line 2: Evaluation of molecular biomarkers in patients treated with psychotropic drugs predisposing to metabolic syndrome<\/strong><\/h4>\n

The presence of multiple factors involved in the pathogenesis, as well as genetic predisposition and lifestyle habits, make it difficult to clarify the mechanisms that determine the course of endocrine disorders such as metabolic syndrome in the general population.<\/p>\n

Therefore, the study in patients under medical control who receive a treatment that predisposes, as a side effect, to the development of metabolic syndrome, allows us to obtain information about biomarkers linked to mechanisms of action, such as key elements of the retinoid system, and others linked to individual susceptibility factors, such as paraoxonase. It is proposed that the determination of such biomarkers would facilitate the identification of risk groups.<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Members” _builder_version=”4.2.2″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n\n\n\n\n\n\n\n\n
Name<\/strong><\/td>\nPosition<\/strong><\/td>\ne-mail<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Dr. Javier Esteban Mozo<\/td>\nPhD Assistant Lecturer<\/td>\njesteban@umh.es<\/a><\/td>\n0000-0003-3760-8223<\/td>\n<\/tr>\n
Dr. Jose Barril Antu\u00f1a<\/td>\nAssociate Professor<\/td>\njose.barril@umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n
Dra. M\u00aa de la Cruz Pell\u00edn Mira<\/td>\nAssociate Professor<\/td>\nmc.pellin@umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n
Roger Ortiz Climent<\/td>\nPhD student<\/td>\nroger.ortizc@umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n
Suylen Galb\u00e1n Vel\u00e1zquez<\/td>\nPhD student<\/td>\nsuylen.galban@goumh.umh.es<\/a><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_tab][et_pb_tab title=”Publications” _builder_version=”4.2.2″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n

S. Galb\u00e1n-Vel\u00e1zquez, J. Esteban, G. \u00c7akmak, F. Artacho-Cord\u00f3n, J. Le\u00f3n, J. Barril, F. Vela-Soria, P. Martin-Olmedo, M. F Fernandez, M. C. Pell\u00edn, J. P Arrebola
Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment<\/a><\/strong>
Environmental Research (2021).<\/p>\n

 <\/p>\n

R. Pohjanvirta, I. Karppinen, S. Galb\u00e1n-Vel\u00e1zquez, J. Esteban, H. H\u00e5kansson, S. Sankari, J. Lind\u00e9n
Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats<\/a><\/strong>
The Journal of Nutritional Biochemistry, Volume 95 (2021).<\/p>\n

 <\/p>\n

M. Herlin, I. S\u00e1nchez-P\u00e9rez, J. Esteban, M. Korkalainen, X. Barber, M.A.J. Finnil\u00e4, G. Hamscher, B. Joseph, M. Viluksela, H. H\u00e5kansson
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data<\/a><\/strong>
Reproductive Toxicology\u00a0105:25-43 (2021).<\/p>\n

 <\/p>\n

S. Alarc\u00f3n, J. Esteban, R. Roos, P. Heikkine, I. S\u00e1nchez-P\u00e9rez, A. Adamsson, J. Toppari, A. Koskela, M.A.J. Finnil\u00e4, J Tuukkanen, M Herlin, G Hamscher, H.A. Leslie, M. Korkalainen, K Halldin, D. Schrenk, H. H\u00e5kansson, M. Viluksela
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2\u2032,3,4,4\u2032,5,5\u2032-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats<\/a><\/strong>
Reproductive Toxicology 102:109-127 (2021).<\/p>\n

 <\/p>\n

J. Esteban, I. S\u00e1nchez-P\u00e9rez, G. Hamscher, H. M Miettinen, M. Korkalainen, M. Viluksela, R. Pohjanvirta, H. H\u00e5kansson
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice<\/a><\/strong>
Reproductive Toxicology\u00a0101:33-49\u00a0(2021).<\/p>\n

 <\/p>\n

J. Esteban, M. Serrano-Maci\u00e1, I. S\u00e1nchez-P\u00e9rez, P. Alonso-Magdalena, M. C. Pell\u00edn, M. Garc\u00eda-Ar\u00e9valo, \u00c1. Nadal, J. Barril
In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring<\/a><\/strong>
Food and Chemical Toxicology (2019).<\/p>\n

 <\/p>\n

S. Mahiout, J. Lind\u00e9n, J. Esteban, I. S\u00e1nchez-P\u00e9rez, S. Sankari, L. Pettersson, H. H\u00e5kansson, R. Pohjanvirta
Toxicological characterisation of two novel selective aryl hydrocarbon receptor modulators in Sprague-Dawley rats<\/a><\/strong>
Toxicology and Applied Pharmacology (2017).<\/p>\n

 <\/p>\n

J. Esteban, L. E. Elabbas, D. Borg, M. Herlin, A. \u00c5kesson, X. Barber, G. Hamscher, H. Nau, W. J. Bowers, J. S. N., M. Viluksela, H. H\u00e5kanssona
Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring<\/a><\/strong>
Toxicology Letters (2014).<\/p>\n

 <\/p>\n

M. Viluksela, P. Heikkinen, L. T. M. van der Ven, F. Rendel, R. Roos, J. Esteban,M. Korkalainen,S. Lensu,H. M. Miettinen, K. Savolainen, S. Sankari, H. Lilienthal, A. Adamsson, J. Toppari, M. Herlin, M. Finnil\u00e4, J. Tuukkanen, H. A. Leslie, T. Hamers, G. Hamscher, L. Al-Anati, U. Stenius, K. Dervola, I. Bogen, F. Fonnum, P. L. Andersson, D. Schrenk, K. Halldin, H. H\u00e5kansson
Toxicological profile of ultrapure 2,2\u2032,3,4,4\u2032,5,5\u2032- heptachlorbiphenyl (PCB 180) in adult rats<\/a><\/strong>
PLoS ONE (2014).<\/p>\n

 <\/p>\n

C. L\u00f3pez-Granero, D. Cardona, E. Gim\u00e9nez, R. Lozano, J. Barril, M. Aschner, F. S\u00e1nchez-Santed, F. Ca\u00f1adas
<\/span>Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression<\/span><\/a><\/span><\/strong>
Neurotoxicology (2014).<\/span><\/p>\n

 <\/p>\n

[\/et_pb_tab][et_pb_tab title=”Projects” _builder_version=”4.2.2″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]<\/p>\n

Contrato para la realizaci\u00f3n del trabajo \u00abEvaluaci\u00f3n de la respuesta del marcador de inflamaci\u00f3n RBP4 en suero de humanos expuestos a contaminantes ambientales que causan estr\u00e9s oxidativo. Funding agency: Fundaci\u00f3n para la Investigaci\u00f3n Biosanitaria de Andaluc\u00eda Oriental. Duration: 03\/12\/2020 \u2013 02\/08\/2021.
PI: Javier Esteban<\/em><\/p>\n

\n

Contrato para la realizaci\u00f3n del trabajo “Comparaci\u00f3n del perfil retinoide en ratas con alelos silvestre y noqueado del gen AhR”. Funding agency: Helsingin Yliopisto. Duration: 20\/12\/2018 \u2013 19\/12\/2019.
PI: Javier Esteban<\/em><\/p>\n

\n

Contrato para la realizaci\u00f3n del trabajo “Determinaci\u00f3n de compuestos retinoides en muestras de animales de experimentaci\u00f3n tratados con contaminantes org\u00e1nicos persistentes\u201d. Funding agency: Karolinska Institutet. Duration: 10\/03\/2014 \u2013 09\/12\/2018.
PI: Javier Esteban<\/em><\/p>\n

\n

Contrato para la realizaci\u00f3n del trabajo “Determinaci\u00f3n de compuestos retinoides en muestras de animales de experimentaci\u00f3n tratados con agonistas AhR”. Funding agency: Helsingin Yliopisto. Duration: 19\/05\/2016 \u2013 18\/05\/2017.
PI: Javier Esteban<\/em><\/p>\n

\n

Raising the awareness of healthy food and healthy eating among children. Funding agency: European Commission 2011-1-TR1-LEO04-27384. Duration: 01\/08\/2011 \u2013 31\/07\/2013.
PI:Javier Esteban<\/em><\/p>\n

\n

<!–<\/p>\n

Contrato para la realizaci\u00f3n del trabajo “Evaluaci\u00f3n de la respuesta del marcador de inflamaci\u00f3n RBP4 en suero de humanos expuestos a contaminantes ambientales que causan estr\u00e9s. Funding agency: FIBAO1.20T. Duration: 03\/12\/2020 – 03\/2\/2021.
PI: Javier Esteban<\/em><\/p>\n

\n

Raising the awareness of healthy food and healthy eating among children. Funding agency: European Commission 2011-1-TR1-LEO04-27384. Duration: 01\/08\/2011 – 31\/07\/2013.
PI: Javier Esteban<\/em><\/p>\n

\n

Disruption of the retinoid system by non-dioxin-like polychlorinated byphenyls present in food. Funding agency: Proyectos BANCAJA-UMH. Duration: 01\/01\/2009 – 31\/12\/2010.
PI: Javier Esteban<\/em><\/p>\n

\n

Efectos neurotoxicos a largo plazo de la exposicion a compuestos organofosforados: Implicacion de nuevas variantes de las enzimas ache y otras carboxilesterasas. Funding agency: Becas y ayudas para el fomento de la investigacion cientifica y el desarrollo tecnologico e\\gv07\/158. Duration: 01\/01\/2007 – 31\/12\/2008.
PI: Jos\u00e9 Ram\u00f3n Barril<\/em><\/p>\n

\n

Influencia de la comedicacion de antirretrovirales y psicofarmacos en los niveles plasmaticos. Funding agency: Conselleria de sanidad. Duration: 18\/02\/2005 – 31\/12\/2005.
PI: Javier Esteban<\/em><\/p>\n

–><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Activities” _builder_version=”4.2.2″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em”]Grupo cient\u00edfico de expertos de la Organizaci\u00f3n para la Cooperaci\u00f3n y el Desarrollo Econ\u00f3micos. OCDE. 2021. No. 343 Detailed review paper on the Retinoid System. Publications on Testing and Assessment. European Commission Framework Contract ENV.A.3\/FRA\/2014\/0029 on Implementation of the Community Strategy on Endocrine Disruptors: Supporting the development of the OECD detailed review paper on the retinoid system.<\/p>\n

Job title<\/strong>: Alteration of the retinoid system due to exposure to xenobiotics.
\nWithin the Program<\/strong>: PhD in Bioengineering (RD 1393\/2007)
\nProject type<\/strong>: Doctoral Thesis
\nEntity<\/strong>: Universidad Miguel Hern\u00e1ndez
\nStudent<\/strong>: Sanchez P\u00e9rez, Ismael
\nQualification obtained<\/strong>: Sobresaliente Cum Laude
\nDate<\/strong>: 22\/09\/2017<\/p>\n

Job title: <\/strong>Toxicity of brominated flame retardants with focus on retinoid system disturbances
\nWithin the Program<\/strong> : Karolinska Institutet
\nProject type<\/strong>: Doctoral Thesis
\nEntity<\/strong>: Universidad Miguel Hern\u00e1ndez
\nStudent<\/strong>: Sabina Litens Karlsson
\nQualification obtained<\/strong>: Sobresaliente Cum Laude
\nDate<\/strong>: 08\/06\/2015<\/p>\n

Name of the exhibition: <\/strong>Raising the awareness of healthy food and healthy eating among children
\nAuthors<\/strong>: Esteban, J.; Barril, J.; E. Garcia Garcia; Pell\u00edn, M.C.
\nForum where it is exposed<\/strong>: HEALTHY FOOD \u2013 EUROPEAN COMMISSION
\nStart date<\/strong>: 01\/08\/2011
\nAvailable at<\/strong>: Alimentaci\u00f3n saludable para una vida sana<\/a>. ISBN 978-84-16024-02-5[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.2.2″ disabled=”on”][et_pb_row _builder_version=”4.2.2″][et_pb_column type=”4_4″ _builder_version=”4.2.2″][:es _i=”0″ _address=”4.0.0.0″ \/][:en _i=”1″ _address=”4.0.0.1″ \/][: _i=”2″ _address=”4.0.0.2″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Responsable Dr. Javier Esteban Mozo   RESUMEN DE LA INVESTIGACI\u00d3N El grupo de investigaci\u00f3n tiene como objetivo central el estudio de mecanismos de toxicidad y factores modificadores, tanto gen\u00e9ticos como ambientales, que afectan a la respuesta de las poblaciones expuestas a contaminantes ambientales, tales como compuestos org\u00e1nicos persistentes y alteradores endocrinos, f\u00e1rmacos y sustancias adictivas. […]<\/p>\n","protected":false},"author":17017,"featured_media":0,"parent":4267,"menu_order":77,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4564"}],"collection":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/users\/17017"}],"replies":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/comments?post=4564"}],"version-history":[{"count":0,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4564\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4267"}],"wp:attachment":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/media?parent=4564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}