{"id":8376,"date":"2022-11-28T10:11:25","date_gmt":"2022-11-28T10:11:25","guid":{"rendered":"https:\/\/bioingenieria.umh.es\/?page_id=8376"},"modified":"2022-11-30T12:06:32","modified_gmt":"2022-11-30T12:06:32","slug":"grupo-de-farmacologia-clinica","status":"publish","type":"page","link":"https:\/\/bioingenieria.umh.es\/en\/unidad-de-toxicologia\/grupo-de-farmacologia-clinica\/","title":{"rendered":"Clinical Pharmacology Group"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” admin_label=”Secci\u00f3n” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_fullwidth_header title=”Grupo de S\u00edntesis Molecular” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”4.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”section” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.16″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”][et_pb_tab title=”Informaci\u00f3n” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n
Responsable<\/strong><\/td>\nFernando Fern\u00e1ndez L\u00e1zaro<\/td>\n<\/tr>\n
Web propia<\/strong><\/td>\nhttp:\/\/quimicaorganica.umh.es<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESUMEN DE LA INVESTIGACI\u00d3N<\/strong><\/h4>\n

Desde su descubrimiento, las perilendiimidas (PDI) han atra\u00eddo mucha atenci\u00f3n gracias a su fuerte absorci\u00f3n de la luz visible, sus elevados rendimientos cu\u00e1nticos de fluorescencia y su estabilidad t\u00e9rmica, qu\u00edmica y fotoqu\u00edmica. Otra vuelta de tuerca se produjo con la llegada de la optoelectr\u00f3nica org\u00e1nica, ya que los PDI se revelaron como excelentes materiales transportadores de electrones con altas afinidades electr\u00f3nicas. Como resultado de todo lo anterior, se han estudiado exhaustivamente en c\u00e9lulas solares (org\u00e1nicas, sensibilizadas por colorantes y basadas en perovskitas), dispositivos emisores de luz, l\u00e1seres, transistores de efecto de campo, sistemas fotosint\u00e9ticos artificiales, sensores y en diferentes aplicaciones biol\u00f3gicas.<\/p>\n

\"s\u00edntesis<\/a><\/p>\n

Esquema de un LED basado en PDI preparado en nuestro grupo.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/h4>\n

 <\/p>\n

L\u00ednea 1:\u00a0Nuevos m\u00e9todos de s\u00edntesis y modificaci\u00f3n de perilendiimidas<\/strong><\/h4>\n

La gran variedad de aplicaciones de las PDIs requiere el ajuste del empaquetamiento molecular y de las propiedades \u00f3pticas y electr\u00f3nicas, lo que puede lograrse mediante la introducci\u00f3n de sustituyentes adecuados en su estructura. En nuestro grupo estamos interesados en la b\u00fasqueda de nuevas y m\u00e1s eficientes formas de modificar la estructura qu\u00edmica de las PDIs, permitiendo as\u00ed la adaptaci\u00f3n de las propiedades para la aplicaci\u00f3n deseada.<\/p>\n

\"s\u00edntesis<\/p>\n

La introducci\u00f3n de los sustituyentes adecuados en el andamio de la PDI permite modificar las propiedades de las PDI como, por ejemplo, el espectro de absorci\u00f3n y, por tanto, el color en soluci\u00f3n.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 2:\u00a0Tintes org\u00e1nicos para l\u00e1ser<\/strong><\/h4>\n

Los PDIs representan una excelente opci\u00f3n para los l\u00e1seres org\u00e1nicos porque no s\u00f3lo presentan buenas propiedades de emisi\u00f3n y sintonizaci\u00f3n de longitudes de onda, sino tambi\u00e9n una buena estabilidad t\u00e9rmica y \u00f3ptica y una alta movilidad de los electrones. Adem\u00e1s, las propiedades \u00f3pticas y electr\u00f3nicas de los PDI pueden adaptarse introduciendo los sustituyentes adecuados, lo que da lugar a l\u00e1seres de estado s\u00f3lido de alto rendimiento.<\/p>\n

\u00a0\"s\u00edntesis<\/p>\n

Esquema de un l\u00e1ser preparado con uno de nuestros PDI.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 3:\u00a0S\u00edntesis de materiales org\u00e1nicos para la fotovoltaica<\/strong><\/h4>\n

Nuestro grupo trabaja activamente en la incorporaci\u00f3n de perilendiimidas como componentes fotoactivos en diferentes dispositivos de c\u00e9lulas solares: c\u00e9lulas solares org\u00e1nicas p-n, como aceptores de no-fullereno en c\u00e9lulas solares de heterouni\u00f3n masiva, como fotosensibilizadores en c\u00e9lulas solares sensibilizadas por colorantes, en c\u00e9lulas solares de perovskita, y tambi\u00e9n como intercalares que act\u00faan como materiales transportadores de electrones o de huecos. Como paso previo, investigamos las propiedades fotof\u00edsicas de los PDI en relaci\u00f3n con la transferencia de energ\u00eda y\/o electrones fotoinducida. Tambi\u00e9n estamos interesados en el uso de PDIs en sistemas fotosint\u00e9ticos artificiales.<\/p>\n

\"s\u00edntesis<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Miembros” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
Nombre<\/strong><\/td>\nPuesto<\/strong><\/td>\nCorreo<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Fernando Fern\u00e1ndez L\u00e1zaro<\/td>\nCatadr\u00e1tico de Universidad<\/td>\nfdofdez@umh.es<\/a><\/td>\n0000-0002-4598-6024<\/td>\n<\/tr>\n
Enrique Font Sanchis<\/td>\nProfesor Titular de Universidad<\/td>\nenrique.font@umh.es<\/a><\/td>\n0000-0002-5082-3107<\/td>\n<\/tr>\n
Ana Mar\u00eda Guti\u00e9rrez V\u00edlchez<\/td>\nProfesora Contratada Doctora<\/td>\nanavil@umh.es<\/a><\/td>\n0000-0002-9310-4022<\/td>\n<\/tr>\n
Nathalie Zink Lorre<\/td>\nProfesora Ayudante Doctora<\/span><\/strong><\/td>\nnzink@umh.es<\/a><\/td>\n0000-0003-3081-995X<\/td>\n<\/tr>\n
Jose Garc\u00e9s Garc\u00e9s<\/td>\nDoctorando<\/td>\njgarces@umh.es<\/a><\/td>\n0000-0002-7637-3140<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"s\u00edntesis<\/a><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Publicaciones” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

A. Scalabre, A. M. Guti\u00e9rrez-V\u00edlchez, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro, D. M. Bassani y R. Oda
Supramolecular Induction of Topological Chirality fron Nanoscale Helical Silica Scaffolds to Achiral Molecular Chromophores<\/a><\/strong>
J. Phys. Chem. C 124, 23839-23843 (2020)<\/p>\n

I. Papadopoulos, D. Guti\u00e9rrez-Moreno, P. M. McCosker, R. Casillas, P. A. Keller, \u00c1. Sastre-Santos, T. Clark, F. Fern\u00e1ndez-L\u00e1zaro y D. M. Guldi
Perylene-Monoimides: Singlet Fission Down-Conversion Competes with Up-Conversion by Geminate Triplet-Triplet Recombination<\/strong><\/a>
J. Phys. Chem. A 124, 5727\u20135736 (2020)<\/p>\n

E. J. Canto-Aguilar, D. Guti\u00e9rrez-Moreno, \u00c1. Sastre-Santos, D. Morikawa, M. Abe, F. Fern\u00e1ndez-L\u00e1zaro, G. Oskam y S. Mori.
Identification of the Loss Mechanisms in TiO2 and ZnO Solar Cells Based on Blue, Piperidinyl-Substituted, Mono-Anhydride Perylene Dyes<\/strong><\/a>
Electrochim. 355, 136638 1-11 (2020)<\/p>\n

N. Zink-Lorre, E. Font-Sanchis, \u00c1. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Perylenediimides as More than Just Non-Fullerene Acceptors: Versatile Components in Organic, Hybrid and Perovskite Solar Cells<\/strong><\/a>
Chem. Commun. 56, 3824-3838 (2020)<\/p>\n

V. Navarro-P\u00e9rez, A. M. Guti\u00e9rrez-V\u00edlchez, J. Ortiz, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro, S. Seetharaman, M. J. Duffy, P. A. Karr y F. D\u2019Souza
A Zinc Phthalocyanine-Benzoperylenetriimide Conjugate for Solvent Dependent Ultrafast Energy vs. Electron Transfer<\/strong><\/a>
Chem. Commun. 55, 14946-14949 (2019)<\/p>\n

N. Zink-Lorre, A. Doncel-Gim\u00e9nez, E. Font-Sanchis, J. Calbo, A. Sastre-Santos, E. Ort\u00ed y F. Fern\u00e1ndez-L\u00e1zaro
Diels-Alder Reaction on Perylenediimides: Synthesis and Theoretical Study of Core-Expanded Diimides<\/strong><\/a>
Org. Chem. Front. 6, 2860-2871 (2019)<\/p>\n

D. Guti\u00e9rrez-Moreno, A. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Direct Amination and N-Heteroarylation of Perylenediimides<\/strong><\/a>
Org. Chem. Front. 6, 2488-2499 (2019)<\/p>\n

N. Zink-Lorre, E. Font-Sanchis, S. Seetharaman, P. A. Karr, A. Sastre-Santos, F. D\u2019Souza y F. Fern\u00e1ndez-L\u00e1zaro
Directly Linked Zinc Phthalocyanine-Perylenediimide Dyads and a Triad for Ultrafast Charge Separation<\/strong><\/a>
Chem.-Eur. J. 25, 10123-10132 (2019)<\/p>\n

R. Mu\u00f1oz-M\u00e1rmol, N. Zink-Lorre, J. M. Villalvilla, P. G. Boj, J. A. Quintana, C. V\u00e1zquez, A. Anderson, M. J. Gordon, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro y M. A. D\u00edaz-Garc\u00eda
Influence of Blending Ratio and Polymer Matrix on the Lasing Properties of Perylenediimide Dyes<\/strong><\/a>
J. Phys. Chem. C 122, 24896-24906 (2018)<\/p>\n

D. Guti\u00e9rrez-Moreno, \u00c1. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Synthesis of Bay-Triaminosubstituted Perylenediimides<\/strong><\/a>
Org. Chem. Front. 5, 1830-1834 (2018)<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Proyectos” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

 <\/p>\n

Perilenodiimidas: transferencia electr\u00f3nica fotoinducida en sistemas multicromof\u00f3ricos, fisi\u00f3n singlete y l\u00e1seres. Preparaci\u00f3n de SURMOF basados en PDI. (PID2019-109200GB-I00). Agencia de financiaci\u00f3n: Agencia Estatal de Investigaci\u00f3n \/ Ministerio de Ciencia e Innovaci\u00f3n. Vigencia: 01\/06\/2020-31\/05\/2023.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

Perilenodiimidas para dispositivos fotovoltaicos y para l\u00e1seres. Estudio del aumento de la conjugaci\u00f3n de perilenodiimidas. (CTQ2016-77039-R). Agencia de financiaci\u00f3n: Ministerio de Econom\u00eda, Industria y Competitividad. Vigencia: 30\/12\/2016-31\/12\/2020.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

S\u00edntesis de perilenodiimidas para c\u00e9lulas solares org\u00e1nicas. Estudio de reactividad de perilenodiimidas y aplicaci\u00f3n en sondas fluorog\u00e9nicas. (CTQ2013-47922-R). Agencia de financiaci\u00f3n: Ministerio de Econom\u00eda y Competitividad. Vigencia: 1\/01\/2014-30\/06\/2017.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

Perilenos y perilenos pi-extendidos: aplicaciones en dispositivos fotovoltaicos, diodos emisores de luz, cristales l\u00edquidos y biomarcadores. (CTQ2010-20349). Agencia de financiaci\u00f3n: Ministerio de Ciencia e Innovaci\u00f3n. Vigencia: 1\/01\/2011-30\/09\/2014.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

S\u00edntesis de compuestos fotoactivos y fotoemisores para la preparaci\u00f3n de c\u00e9lulas solares org\u00e1nicas y diodos emisores de luz org\u00e1nicos. (CTQ2007-67888\/BQU). Agencia de financiaci\u00f3n: Ministerio de Educaci\u00f3n y Ciencia. Vigencia: 1\/10\/2007-30\/12\/2010.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Secci\u00f3n” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_fullwidth_header title=”Clinical Pharmacology Group” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”4.17.4″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.17.4″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}” sticky_enabled=”0″][et_pb_tab title=”Information” _builder_version=”4.17.4″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n
Responsible<\/strong><\/td>\nAna Mar\u00eda Peir\u00f3 Peir\u00f3<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESEARCH SUMMARY<\/strong><\/h4>\n

In the Clinical Pharmacology Group we investigate interindividual variability in drug response, especially in the area of pain and cognitive diversity. Our work focuses on the monitoring of adverse events and the use of pharmacogenetic markers to improve the benefit\/risk of drugs. To this end, we have specific lines of work on drugs abuse and dependence, as well as sleep disorders. The analysis of sex\/gender interaction is included as a cross-cutting theme in all of them.<\/p>\n

RESEARCH LINES<\/strong><\/h4>\n

Line1: Pharmacogenetics<\/strong><\/h4>\n

The group is made up of researchers and trainees with expertise in the field of Pharmacogenetics. As a multidisciplinary group, is composed by specialists in various disciplines such as doctors, pharmacists, biologists and biotechnologists.<\/p>\n

The group offers the medical and scientific community all its experience and know-how in the determination of genetic polymorphisms associated with clinical pathologies and the response to pharmacological treatments, as an approach to precision medicine. Currently, panels of gene polymorphisms linked to pharmacokinetics (metabolism and transport) and pharmacodynamics linked to the area of analgesics and psychotropic drugs are available in a predefined form. However, advice is offered on the design of personalised polymorphism\/gene panels for the development of research studies: prospective, retrospective; by pathology, by gene, by drug; or at translational research level.<\/p>\n

Line 2: Prevention of problematic drug use<\/strong><\/h4>\n

To identify individual risk factors in the non-medical use of analgesics and psychotropic drugs, applied to pain medicine and also in other areas of health, such as sports medicine. There is also a line of work on the analysis of motivation and expectations, which can lead to these behaviours. The group has experience in training and prevention of doping.<\/p>\n

Line 3: Research into sex\/gender interaction in pain medicine<\/strong><\/h4>\n

The group\u2019s link with clinical services of the Hospital General Dr. Balmis de Alicante, allows the inclusion of the gender perspective in clinical research lines. This qualitative analysis of the influence of gender in the clinical management of diseases allows us to glimpse areas for improvement in order to achieve greater equity in our health system.<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Members” _builder_version=”4.17.4″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
Name<\/strong><\/td>\nPosition<\/strong><\/td>\ne-mail<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Ana Mar\u00eda Peir\u00f3 Peir\u00f3<\/td>\nAssociate Professor<\/td>\napeiro@umh.es<\/a><\/td>\n0000-0002-2385-3749<\/td>\n<\/tr>\n
Javier Muriel Serrano<\/td>\nPart-time Lecturer<\/td>\njmuriel@umh.es<\/a><\/td>\n0000-0003-0048-9451<\/td>\n<\/tr>\n
Pura Ballester Navarro<\/td>\n\u00a0<\/td>\npuraballesternavarro@gmail.com<\/a><\/td>\n0000-0002-7345-448X<\/td>\n<\/tr>\n
Thomas Zandonai<\/td>\n\u00a0<\/td>\nthomaszandonai@gmail.com<\/a><\/td>\n0000-0002-7606-9675<\/td>\n<\/tr>\n
M\u00f3nica Escorial<\/td>\n\u00a0<\/td>\nmonicaescorial@hotmail.com<\/a><\/td>\n0000-0003-3235-1879<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Publications” _builder_version=”4.17.4″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

P. Barrachina, C. Margarit, J. Muriel, S. L\u00f3pez\u2011Gil, V. L\u00f3pez\u2011Gil, A. Vara\u2011Gonz\u00e1lez, B. Planelles, MM. Inda, D. Morales, AM. Peir\u00f3.<\/span>
Oxycodone\/naloxone versus tapentadol in real\u2011world chronic non\u2011cancer pain management: an observational and pharmacogenetic study.<\/b><\/a><\/strong>
Scientific Reports (2022).<\/span><\/p>\n

P. Ballester, J. Muriel, AM. Peir\u00f3<\/span>
CYP2D6 phenotypes and opioid metabolism: the path to personalized analgesia.<\/b><\/a><\/strong>
Expert Opin Drug Metab Toxicol (2022).<\/span><\/p>\n

P. <\/span>Ballester, C. Espadas, AC. Londo\u00f1o, S. Almenara, V. Aguilar, C. Belda, E. P\u00e9rez, J. Muriel, AM. Peir\u00f3.<\/span>
The challenge of detecting adverse events in adults with autism spectrum disorder who have intellectual disability.<\/b><\/a><\/strong>
Autism Research (2021).<\/span><\/p>\n

J. Barrachina , J. Muriel , C. Margarit, B. Planelles , P. Ballester, M. Richart-Mart\u00ednez, E. Cutillas, T. Zandonai, D. Morales, AM. Peir\u00f3.
Global Pain State Questionnaire: Reliability, Validity, and Gender Gap.<\/strong><\/a>
Archives of Internal Medicine Research (2021).<\/p>\n

P. Ballester, A.L. Richdale, E.K. Baker, A.M. Peiro<\/span>
Sleep in autism: a biomolecular approach to aetiology and treatment.<\/b><\/a><\/strong>
Sleep Medicine Reviews (2020).<\/span><\/p>\n

M.\u00c1. Pena, J. Muriel, M. Saiz-Rodr\u00edguez, A.M. Borobia, F. Abad-Santos, J. Fr\u00edas, A.M. Peir\u00f3.
Effect of cytochrome P450 and ABCB1 polymorphisms on Imatinib pharmacokinetics after single-dose administration to healthy subjects.<\/strong><\/a>
Clinical Drug Investigation (2020).<\/p>\n

C. Margarit, R. Roca, MM. Inda, J. Muriel, P. Ballester, A. Flor, D. Morales, AM. Peir\u00f3.
Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain.<\/strong><\/a>
The Clinical Journal of Pain (2020).<\/p>\n

P. Ballester P, MJ. Mart\u00ednez, MM. Inda, A. Javaloyes, AL. Richdale, J. Muriel, C. Belda, N. Toral, D. Morales, E. Fern\u00e1ndez, AM. Peir\u00f3.
Evaluation of agomelatine for the treatment of sleep problems in adults with Autism Spectrum Disorder.<\/strong><\/a>
Journal of Psychopharmacology (2019).<\/p>\n

J. Muriel, C. Margarit, J. Barrachina, P. Ballester, A. Flor, D. Morales, JF. Horga, E. Fern\u00e1ndez, AM. Peir\u00f3.
Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients.<\/strong><\/a>
Basic & Clinic Pharmacology & Toxicology (2019).<\/p>\n

J. Muriel, C. Margarit, B. Planelles, MM. Inda, C. Puga, E. Cutillas, MJ. Serralta, JF. Horga, D. Morales, AM. Peir\u00f3.
OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients.<\/strong><\/a>
Annals of the New York Academy of Sciences (2018).<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Projects” _builder_version=”4.17.4″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

Gender biases in pain medicine: pharmacogenetics, pharmacokinetics and metabolomics (SESGEN).
Funding agency: Proyectos de Investigaci\u00f3n Clinica Independiente (ICI 2020). Instituto de Salud Carlos III, ISCIII.
Duration: 2020-2024.
PI: Ana Mar\u00eda Peir\u00f3<\/em><\/p>\n

__________________________________________________________________________________________________________________________________<\/em><\/p>\n

Development and validation of a prescription opioid dependence prediction model (PreDESOPI).
Funding agency: Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL) \u2013 Fundaci\u00f3n FISABIO \u2013 Fundaci\u00f3n Navarro Tripodi. Duration: 2020 \u2013 2023.
PI: Javier Muriel<\/em><\/p>\n

__________________________________________________________________________________________________________________________________<\/em><\/p>\n

Omic sciences applied to pain medicine with analysis of sex\/gender interaction (SESGEN-OMIC).
Funding agency: Ayudas para la realizaci\u00f3n de Acciones entre investigadores de la Universidad Miguel Hern\u00e1ndez e investigadores\/profesionales del Hospital Universitari i Polit\u00e8cnic\/Instituto de Investigaci\u00f3n Sanitaria La Fe (AP2021-06).
Duration: 2021 \u2013 2022.
PI: Ana Mar\u00eda Peir\u00f3 y Mar\u00eda Jos\u00e9 Herrero.<\/em><\/p>\n

__________________________________________________________________________________________________________________________________<\/em><\/p>\n

Deprescription in patients with opioid dependence.
Funding agency: Programa Difunde. Universidad Miguel Hern\u00e1ndez. Duration: 2020-2021.
PI: Ana Mar\u00eda Peir\u00f3<\/em><\/p>\n

__________________________________________________________________________________________________________________________________<\/em><\/p>\n

Pharmacogenetics applied to new opioid drugs for chronic pain.
Funding agency: Universidad Miguel Hern\u00e1ndez. Duration: 2017-2018.
PI: Ana Mar\u00eda Peir\u00f3<\/em><\/p>\n

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[\/et_pb_tab][\/et_pb_tabs][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][:es _i=”0″ _address=”4.0.0.0″ \/][:en _i=”1″ _address=”4.0.0.1″ \/][: _i=”2″ _address=”4.0.0.2″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Responsable Fernando Fern\u00e1ndez L\u00e1zaro Web propia http:\/\/quimicaorganica.umh.es   RESUMEN DE LA INVESTIGACI\u00d3N Desde su descubrimiento, las perilendiimidas (PDI) han atra\u00eddo mucha atenci\u00f3n gracias a su fuerte absorci\u00f3n de la luz visible, sus elevados rendimientos cu\u00e1nticos de fluorescencia y su estabilidad t\u00e9rmica, qu\u00edmica y fotoqu\u00edmica. Otra vuelta de tuerca se produjo con la llegada de la […]<\/p>\n","protected":false},"author":1595,"featured_media":0,"parent":4267,"menu_order":78,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/8376"}],"collection":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/users\/1595"}],"replies":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/comments?post=8376"}],"version-history":[{"count":0,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/8376\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4267"}],"wp:attachment":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/media?parent=8376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}