{"id":8421,"date":"2022-11-29T09:16:51","date_gmt":"2022-11-29T09:16:51","guid":{"rendered":"https:\/\/bioingenieria.umh.es\/?page_id=8421"},"modified":"2022-12-09T20:24:41","modified_gmt":"2022-12-09T20:24:41","slug":"grupo-de-neuroprotesis-y-rehabilitacion-visual","status":"publish","type":"page","link":"https:\/\/bioingenieria.umh.es\/en\/unidad-de-ingenieria-biomedica\/grupo-de-neuroprotesis-y-rehabilitacion-visual\/","title":{"rendered":"Group of Neuroprosthesis and Visual Rehabilitation"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” admin_label=”Secci\u00f3n” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_fullwidth_header title=”Grupo de S\u00edntesis Molecular” text_orientation=”center” content_max_width=”none” admin_label=”T\u00edtulo de anchura completa” _builder_version=”4.16″ background_color=”#649922″ button_one_letter_spacing_hover=”0″ button_two_letter_spacing_hover=”0″ global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”0″ button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”0″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”section” _builder_version=”4.16″ disabled=”on” global_colors_info=”{}”][et_pb_row padding_mobile=”off” column_padding_mobile=”on” admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”980px” make_fullwidth=”off” use_custom_width=”on” width_unit=”on” custom_width_px=”980px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_tabs admin_label=”Pesta\u00f1as” _builder_version=”4.16″ tab_font=”Roboto||||” tab_line_height=”1.4em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”][et_pb_tab title=”Informaci\u00f3n” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n
Responsable<\/strong><\/td>\nFernando Fern\u00e1ndez L\u00e1zaro<\/td>\n<\/tr>\n
Web propia<\/strong><\/td>\nhttp:\/\/quimicaorganica.umh.es<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESUMEN DE LA INVESTIGACI\u00d3N<\/strong><\/h4>\n

Desde su descubrimiento, las perilendiimidas (PDI) han atra\u00eddo mucha atenci\u00f3n gracias a su fuerte absorci\u00f3n de la luz visible, sus elevados rendimientos cu\u00e1nticos de fluorescencia y su estabilidad t\u00e9rmica, qu\u00edmica y fotoqu\u00edmica. Otra vuelta de tuerca se produjo con la llegada de la optoelectr\u00f3nica org\u00e1nica, ya que los PDI se revelaron como excelentes materiales transportadores de electrones con altas afinidades electr\u00f3nicas. Como resultado de todo lo anterior, se han estudiado exhaustivamente en c\u00e9lulas solares (org\u00e1nicas, sensibilizadas por colorantes y basadas en perovskitas), dispositivos emisores de luz, l\u00e1seres, transistores de efecto de campo, sistemas fotosint\u00e9ticos artificiales, sensores y en diferentes aplicaciones biol\u00f3gicas.<\/p>\n

\"s\u00edntesis<\/a><\/p>\n

Esquema de un LED basado en PDI preparado en nuestro grupo.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00cdNEAS DE INVESTIGACI\u00d3N<\/strong><\/h4>\n

 <\/p>\n

L\u00ednea 1:\u00a0Nuevos m\u00e9todos de s\u00edntesis y modificaci\u00f3n de perilendiimidas<\/strong><\/h4>\n

La gran variedad de aplicaciones de las PDIs requiere el ajuste del empaquetamiento molecular y de las propiedades \u00f3pticas y electr\u00f3nicas, lo que puede lograrse mediante la introducci\u00f3n de sustituyentes adecuados en su estructura. En nuestro grupo estamos interesados en la b\u00fasqueda de nuevas y m\u00e1s eficientes formas de modificar la estructura qu\u00edmica de las PDIs, permitiendo as\u00ed la adaptaci\u00f3n de las propiedades para la aplicaci\u00f3n deseada.<\/p>\n

\"s\u00edntesis<\/p>\n

La introducci\u00f3n de los sustituyentes adecuados en el andamio de la PDI permite modificar las propiedades de las PDI como, por ejemplo, el espectro de absorci\u00f3n y, por tanto, el color en soluci\u00f3n.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 2:\u00a0Tintes org\u00e1nicos para l\u00e1ser<\/strong><\/h4>\n

Los PDIs representan una excelente opci\u00f3n para los l\u00e1seres org\u00e1nicos porque no s\u00f3lo presentan buenas propiedades de emisi\u00f3n y sintonizaci\u00f3n de longitudes de onda, sino tambi\u00e9n una buena estabilidad t\u00e9rmica y \u00f3ptica y una alta movilidad de los electrones. Adem\u00e1s, las propiedades \u00f3pticas y electr\u00f3nicas de los PDI pueden adaptarse introduciendo los sustituyentes adecuados, lo que da lugar a l\u00e1seres de estado s\u00f3lido de alto rendimiento.<\/p>\n

\u00a0\"s\u00edntesis<\/p>\n

Esquema de un l\u00e1ser preparado con uno de nuestros PDI.<\/span><\/strong><\/em><\/p>\n

 <\/p>\n

L\u00ednea 3:\u00a0S\u00edntesis de materiales org\u00e1nicos para la fotovoltaica<\/strong><\/h4>\n

Nuestro grupo trabaja activamente en la incorporaci\u00f3n de perilendiimidas como componentes fotoactivos en diferentes dispositivos de c\u00e9lulas solares: c\u00e9lulas solares org\u00e1nicas p-n, como aceptores de no-fullereno en c\u00e9lulas solares de heterouni\u00f3n masiva, como fotosensibilizadores en c\u00e9lulas solares sensibilizadas por colorantes, en c\u00e9lulas solares de perovskita, y tambi\u00e9n como intercalares que act\u00faan como materiales transportadores de electrones o de huecos. Como paso previo, investigamos las propiedades fotof\u00edsicas de los PDI en relaci\u00f3n con la transferencia de energ\u00eda y\/o electrones fotoinducida. Tambi\u00e9n estamos interesados en el uso de PDIs en sistemas fotosint\u00e9ticos artificiales.<\/p>\n

\"s\u00edntesis<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Miembros” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
Nombre<\/strong><\/td>\nPuesto<\/strong><\/td>\nCorreo<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Fernando Fern\u00e1ndez L\u00e1zaro<\/td>\nCatadr\u00e1tico de Universidad<\/td>\nfdofdez@umh.es<\/a><\/td>\n0000-0002-4598-6024<\/td>\n<\/tr>\n
Enrique Font Sanchis<\/td>\nProfesor Titular de Universidad<\/td>\nenrique.font@umh.es<\/a><\/td>\n0000-0002-5082-3107<\/td>\n<\/tr>\n
Ana Mar\u00eda Guti\u00e9rrez V\u00edlchez<\/td>\nProfesora Contratada Doctora<\/td>\nanavil@umh.es<\/a><\/td>\n0000-0002-9310-4022<\/td>\n<\/tr>\n
Nathalie Zink Lorre<\/td>\nProfesora Ayudante Doctora<\/span><\/strong><\/td>\nnzink@umh.es<\/a><\/td>\n0000-0003-3081-995X<\/td>\n<\/tr>\n
Jose Garc\u00e9s Garc\u00e9s<\/td>\nDoctorando<\/td>\njgarces@umh.es<\/a><\/td>\n0000-0002-7637-3140<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"s\u00edntesis<\/a><\/p>\n

[\/et_pb_tab][et_pb_tab title=”Publicaciones” _builder_version=”4.16″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

A. Scalabre, A. M. Guti\u00e9rrez-V\u00edlchez, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro, D. M. Bassani y R. Oda
Supramolecular Induction of Topological Chirality fron Nanoscale Helical Silica Scaffolds to Achiral Molecular Chromophores<\/a><\/strong>
J. Phys. Chem. C 124, 23839-23843 (2020)<\/p>\n

I. Papadopoulos, D. Guti\u00e9rrez-Moreno, P. M. McCosker, R. Casillas, P. A. Keller, \u00c1. Sastre-Santos, T. Clark, F. Fern\u00e1ndez-L\u00e1zaro y D. M. Guldi
Perylene-Monoimides: Singlet Fission Down-Conversion Competes with Up-Conversion by Geminate Triplet-Triplet Recombination<\/strong><\/a>
J. Phys. Chem. A 124, 5727\u20135736 (2020)<\/p>\n

E. J. Canto-Aguilar, D. Guti\u00e9rrez-Moreno, \u00c1. Sastre-Santos, D. Morikawa, M. Abe, F. Fern\u00e1ndez-L\u00e1zaro, G. Oskam y S. Mori.
Identification of the Loss Mechanisms in TiO2 and ZnO Solar Cells Based on Blue, Piperidinyl-Substituted, Mono-Anhydride Perylene Dyes<\/strong><\/a>
Electrochim. 355, 136638 1-11 (2020)<\/p>\n

N. Zink-Lorre, E. Font-Sanchis, \u00c1. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Perylenediimides as More than Just Non-Fullerene Acceptors: Versatile Components in Organic, Hybrid and Perovskite Solar Cells<\/strong><\/a>
Chem. Commun. 56, 3824-3838 (2020)<\/p>\n

V. Navarro-P\u00e9rez, A. M. Guti\u00e9rrez-V\u00edlchez, J. Ortiz, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro, S. Seetharaman, M. J. Duffy, P. A. Karr y F. D\u2019Souza
A Zinc Phthalocyanine-Benzoperylenetriimide Conjugate for Solvent Dependent Ultrafast Energy vs. Electron Transfer<\/strong><\/a>
Chem. Commun. 55, 14946-14949 (2019)<\/p>\n

N. Zink-Lorre, A. Doncel-Gim\u00e9nez, E. Font-Sanchis, J. Calbo, A. Sastre-Santos, E. Ort\u00ed y F. Fern\u00e1ndez-L\u00e1zaro
Diels-Alder Reaction on Perylenediimides: Synthesis and Theoretical Study of Core-Expanded Diimides<\/strong><\/a>
Org. Chem. Front. 6, 2860-2871 (2019)<\/p>\n

D. Guti\u00e9rrez-Moreno, A. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Direct Amination and N-Heteroarylation of Perylenediimides<\/strong><\/a>
Org. Chem. Front. 6, 2488-2499 (2019)<\/p>\n

N. Zink-Lorre, E. Font-Sanchis, S. Seetharaman, P. A. Karr, A. Sastre-Santos, F. D\u2019Souza y F. Fern\u00e1ndez-L\u00e1zaro
Directly Linked Zinc Phthalocyanine-Perylenediimide Dyads and a Triad for Ultrafast Charge Separation<\/strong><\/a>
Chem.-Eur. J. 25, 10123-10132 (2019)<\/p>\n

R. Mu\u00f1oz-M\u00e1rmol, N. Zink-Lorre, J. M. Villalvilla, P. G. Boj, J. A. Quintana, C. V\u00e1zquez, A. Anderson, M. J. Gordon, \u00c1. Sastre-Santos, F. Fern\u00e1ndez-L\u00e1zaro y M. A. D\u00edaz-Garc\u00eda
Influence of Blending Ratio and Polymer Matrix on the Lasing Properties of Perylenediimide Dyes<\/strong><\/a>
J. Phys. Chem. C 122, 24896-24906 (2018)<\/p>\n

D. Guti\u00e9rrez-Moreno, \u00c1. Sastre-Santos y F. Fern\u00e1ndez-L\u00e1zaro
Synthesis of Bay-Triaminosubstituted Perylenediimides<\/strong><\/a>
Org. Chem. Front. 5, 1830-1834 (2018)<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Proyectos” _builder_version=”4.16″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

 <\/p>\n

Perilenodiimidas: transferencia electr\u00f3nica fotoinducida en sistemas multicromof\u00f3ricos, fisi\u00f3n singlete y l\u00e1seres. Preparaci\u00f3n de SURMOF basados en PDI. (PID2019-109200GB-I00). Agencia de financiaci\u00f3n: Agencia Estatal de Investigaci\u00f3n \/ Ministerio de Ciencia e Innovaci\u00f3n. Vigencia: 01\/06\/2020-31\/05\/2023.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

Perilenodiimidas para dispositivos fotovoltaicos y para l\u00e1seres. Estudio del aumento de la conjugaci\u00f3n de perilenodiimidas. (CTQ2016-77039-R). Agencia de financiaci\u00f3n: Ministerio de Econom\u00eda, Industria y Competitividad. Vigencia: 30\/12\/2016-31\/12\/2020.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

S\u00edntesis de perilenodiimidas para c\u00e9lulas solares org\u00e1nicas. Estudio de reactividad de perilenodiimidas y aplicaci\u00f3n en sondas fluorog\u00e9nicas. (CTQ2013-47922-R). Agencia de financiaci\u00f3n: Ministerio de Econom\u00eda y Competitividad. Vigencia: 1\/01\/2014-30\/06\/2017.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

Perilenos y perilenos pi-extendidos: aplicaciones en dispositivos fotovoltaicos, diodos emisores de luz, cristales l\u00edquidos y biomarcadores. (CTQ2010-20349). Agencia de financiaci\u00f3n: Ministerio de Ciencia e Innovaci\u00f3n. Vigencia: 1\/01\/2011-30\/09\/2014.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

\n

S\u00edntesis de compuestos fotoactivos y fotoemisores para la preparaci\u00f3n de c\u00e9lulas solares org\u00e1nicas y diodos emisores de luz org\u00e1nicos. (CTQ2007-67888\/BQU). Agencia de financiaci\u00f3n: Ministerio de Educaci\u00f3n y Ciencia. Vigencia: 1\/10\/2007-30\/12\/2010.
PI: Fernando Fern\u00e1ndez L\u00e1zaro<\/em><\/p>\n

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Responsible<\/strong><\/td>\nEduardo Fern\u00e1ndez Jover<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

RESEARCH SUMMARY<\/strong><\/h4>\n

We are a multidisciplinary group of specialists in various fields such as engineering, biology, computer science, robotics, medicine, etc. Our main objective is basic and applied research in visual pathologies, optogenetics, the study of therapies against visual neuropathies, the design and development of robotic devices and systems that help improve cognitive and communicative capacity, health and physical capacity. of people with motor and sensory disabilities\u2026<\/p>\n

RESEARCH LINES<\/strong><\/h4>\n

Line 1<\/strong>: Development and validation of a laser-induced choroidal neovascularization model<\/strong><\/h4>\n

The laser-induced choroidal neovascularization model is an established method used to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our older adult population. The main objective of this line is to obtain a validated model to experiment with therapies and treatments for the control and cure of this pathology with the aim of moving to clinical phases in humans with the treatments tested in the animal model in the future.<\/p>\n

\"s\u00edntesis<\/p>\n

Generation of neovascularization by a laser system in the rat retina after 7 days.<\/em><\/p>\n

Line 2:Ophthalmological therapy using interfering RNA (siRNA) and humanized monoclonal antibodies for retinal degenerative pathologies.<\/strong><\/h4>\n

This line of research is based on the application of new molecules based on RNA interference and humanized monoclonal antibodies for chronic pathologies such as age-related macular degeneration (AMD), diabetic retinopathy and retinitis pigmentosa, which currently do not have satisfactory treatments<\/p>\n

Line 3: DRUG4SIGHT: Light-regulated drugs to restore sight<\/strong><\/h4>\n

In degenerative retinal diseases such as retinitis pigmentosa, photoreceptor cells are progressively lost, leading to visual impairment with limited treatment options. This line aims to characterize a series of light-sensitive active compounds that can photosensitize the retina, stimulating proteins still present in the degenerated retina and activating the remaining receptors of non-degenerated cells.<\/em><\/p>\n

Line 4: New generation of multifunctional intraocular for prolonged and controlled release of therapeutic agents at the intraocular level (OCULUS)<\/strong><\/h4>\n

To avoid or reduce effects associated with cataract surgery (pain, infection, inflammation and possible intraocular hemorrhage) it is necessary to administer anti-inflammatory and anti-infective drugs daily for at least 6-8 weeks after surgery. Topical administration of these drugs manages to retain less than 5% of the applied drug after passing through the cornea. For this reason, this line of research focuses on the development of new intraocular lenses that release drugs in a sustained manner in order to obtain a continuous therapeutic dose.<\/p>\n

Line 5: Application of biofilms with Timolol for the control of intraocular pressure (OCULIPID)<\/strong><\/h4>\n

Glaucoma is a progressive visual disease whose most important risk factor is elevated intraocular pressure. Current ocular pharmaceutical formulations have drawbacks in terms of their administration and therapeutic efficacy. This line of research focuses on the topical application of lipid biofilms formulated with prolonged release Timolol to control intraocular pressure in a preclinical experimental model of rabbit glaucoma<\/p>\n

Line 6: Computational modeling environment for evaluating the safety and efficacy of peripheral nervous system stimulation<\/strong><\/h4>\n

The objective of this line is to develop and make available to the scientific community a modular, integrated and multiscale computational modeling framework that will allow the design of safe and effective peripheral neurostimulators. The achievement of this line will be carried out through the three-dimensional reconstruction of the microstructure of stimulated nerves, through histological sections, by a computer-assisted anatomical dissection method. This is intended to improve the description of nerve fiber distribution, provide an accurate 3D representation of the sciatic nerves, and develop a computerized database of nerve fiber topography.<\/p>\n

Line 7: Gene therapy with non-viral vectors for the treatment of neurodegenerative diseases<\/strong><\/h4>\n

Nowadays,the cure to neurodegenerative diseases is a medical problem that is far from being solved. One approach to accomplish a solution is the capability to replace the defective genes involved in the development of such diseases for new fully functional genes capable of disrupting its progression. Gene therapy consists of the transfer of exogenous genetic material for the modification of cells with therapeutic or research purposes. In collaboration with the NanoBioCel group (Micro and Nano Technologies, Biomaterials and Cells Group) of the University of the Basque Country, our group is working on the development of new non-viral vectors to transfer genetic material inside the cells of the nervous system in order to find new therapies for neurological diseases. The great advantages of the non-viral vectors compared to other approaches are their very low or absent of immunogenic\u00a0response in the receptor organisms, their biological and chemical safety for scientist and manufacturers, their capability to transport large genetic fragments inside the cells, and also, their ease of production, handling, storing and low cost of production.\u00a0<\/p>\n

Line 8: Development of Visual Neuroprosthesis<\/strong><\/h4>\n

The NBIO multidisciplinary team led by Prof. Eduardo Fernandez Jover, is made up of a group of medical doctors, surgeons, biologists and engineers focused on the development and improvement of visual prostheses implanted in the visual cortex of blind patients or patients with low vision. The purpose of the group is to ensure that human patients achieve visual functionality that allows them to perform the usual tasks of daily life such as the ability to recognize objects, numerical and alphabetic symbols, as well as the ability to move independently through space. To achieve this aim, the team is involved in the optimization of the cortical implant protocol for surgery, the development and design of new electrodes that improve their biocompatibility with the nervous tissue, as well as in the study and analysis of the neural and perceptual responses of implanted human patients to stimulation through the neuroprosthesis. These studies are complemented by the development of artificial retinal models that attempt to reproduce the real activity of the ganglion cells of the retina in response to the presentation of different visual stimuli. Additionally, the group has built a smart study room that allows to evaluate the behavioral response of patients to the presentation of visual stimuli presented through the stimulation of the visual neuroprosthesis. The study room is a real-scale reproduction of a customizable outdoor space that allows human patients to move and navigate through it as if they would be walking through the city and guided by the presentation of stimuli through the implanted neuroprosthesis.<\/p>\n

Line 9: <\/strong>Optogenetic approach in visual restoration <\/strong><\/h4>\n

The emergence of optogenetics has revolutionized the field of neuroscience and has proved an invaluable tool for manipulating the activity in neurons through photostimulation with high temporal precision and genetic targeted specificity. Photosensitive channels such as channelrhodpsin-2 (ChR2) and the plethora of bioengineered variants which have emerged not only function as an explorative tool in neuroscience but have profound implications in therapy. We aim to use optogenetics as a viable and improved alternative to current approaches in visual restoration in patients with retinitis pigmentaria (RP) who have lost their photoreceptor layer. The introduction of optogenetic proteins into the residual retinal layers can prove clinically viable as a therapy capable of significant and meaningful changes to the quality of their vision and life. We express new improved optogenetic vatiants (CatCh and Chrimson) in the remaining intact retina essentially converting these cells into new basic photoresponsive tissue capable of reinitiating the visual signal and relaying it to the higher visual centers for processing.<\/p>\n

[\/et_pb_tab][et_pb_tab title=”Members” _builder_version=”4.17.4″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Name<\/strong><\/td>\nPosition<\/strong><\/td>\nE-mail<\/strong><\/td>\nORCID<\/strong><\/td>\n<\/tr>\n
Eduardo Fern\u00e1ndez Jover<\/td>\nFull Professor<\/td>\ne.fernandez@umh.es<\/a><\/td>\n\u00a00000-0002-7052-6011<\/td>\n<\/tr>\n
Lawrence Humphreys<\/td>\nPostdoctoral Researcher<\/td>\nlhumphreys@umh.es<\/a><\/td>\n0000-0003-1366-1396<\/td>\n<\/tr>\n
Gema Mart\u00ednez Navarrete<\/td>\nPhD. Assistant Lecturer<\/td>\ngema.martinezn@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Cristina Soto S\u00e1nchez<\/td>\nPhD. Assistant Lecturer<\/td>\ncsoto@umh.es<\/a><\/td>\n0000-0003-4447-5967<\/td>\n<\/tr>\n
Adela Bernabeu Zornoza<\/td>\nPostdoctoral Researcher<\/td>\nadela.bernabeuz@umh.es<\/a><\/td>\n0000-0001-6238-1791<\/td>\n<\/tr>\n
Marcos Adri\u00e1n Villamar\u00edn Ortiz<\/td>\nPostdoctoral Researcher<\/td>\nmvillamarin@umh.es<\/a><\/td>\n0000-0003-2768-9162<\/td>\n<\/tr>\n
M\u00aa \u00c1ngeles Mart\u00ednez Gilabert<\/td>\nPostdoctoral Researcher<\/td>\nmaria.mgilabert@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Roberto Moroll\u00f3n Ru\u00edz<\/td>\nPostdoctoral Researcher<\/td>\nrmorollon@umh.es<\/a><\/td>\n0000\u22120002\u22129903\u22123296<\/td>\n<\/tr>\n
Mikel Val Calvo<\/td>\nPostdoctoral Researcher<\/td>\nmval@umh.es<\/a><\/td>\n0000-0002-1820-7881<\/td>\n<\/tr>\n
Alfonso Rodil Doblado<\/td>\nPostdoctoral Researcher<\/td>\narodil@umh.es<\/a><\/td>\n0000-0001-8956-3886<\/td>\n<\/tr>\n
Leili Soo<\/td>\nPostdoctoral Researcher<\/td>\nlsoo@umh.es<\/a><\/td>\n0000-0002-3035-0007<\/td>\n<\/tr>\n
Fabrizio Grani<\/td>\nPostdoctoral Researcher<\/td>\nfgrani@umh.es<\/a><\/td>\n0000-0003-4270-6450<\/td>\n<\/tr>\n
Roc\u00edo L\u00f3pez Peco<\/td>\nPostdoctoral Researcher<\/td>\nrocio.lopezp@umh.es<\/a><\/td>\n0000\u22120003\u22121711\u22129561<\/td>\n<\/tr>\n
Jos\u00e9 David Celdr\u00e1n L\u00f3pez<\/td>\nPostdoctoral Researcher<\/td>\njceldran@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Alejandro Gombau Garc\u00eda<\/td>\nPostdoctoral Researcher<\/td>\nagombau@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Cristina Garc\u00eda Miralles<\/td>\nPostdoctoral Researcher<\/td>\ncristina.garciam@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Magdalena Cornejo Gonz\u00e1lez<\/td>\nManagement Technician<\/td>\nmcornejo@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Sonia Andreu Vera<\/td>\nLaboratory Technician<\/td>\nsandreu@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Desir\u00e9e Gonz\u00e1lez Gras<\/td>\nLaboratory Technician<\/td>\ndgonzalez@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n
Juan Manuel Morcillo de Miguel<\/td>\nLaboratory Technician<\/td>\njmorcillo@umh.es<\/a><\/td>\n\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_tab][et_pb_tab title=”Publications” _builder_version=”4.17.4″ body_font=”Roboto||||” body_line_height=”2em” tab_font=”Roboto||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

\u00a0N. Al Qtaish, I. Gallego, A.J. Paredes, I. Villate-Beitia, C. Soto-S\u00e1nchez, G. Mart\u00ednez-Navarrete, M. Sainz-Ramos, T. B. L\u00f3pez-M\u00e9ndez, E. Fern\u00e1ndez, G. Puras, J.L. Pedraz.
Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases.<\/strong><\/a>
ACS Appl. Mater. Interfaces 14(11):13665-13677 (2022).<\/p>\n

E. Fern\u00e1ndez, A. Alfaro, C. Soto-S\u00e1nchez, P. Gonz\u00e1lez-L\u00f3pez, A.M. Lozano, S. Pe\u00f1a, M.D. Grima, A. Rodil, B. G\u00f3mez, X. Chen, P.R. Roelfsema, J.D. Rolston, T.S. Davis, R.A. Normann.<\/p>\n

\u00a0Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex.<\/a><\/strong>
J. Clin. Invest.131(23):e151331 (2021).<\/p>\n

X. Chen, F. Wang, E. Fern\u00e1ndez, P.R. Roelfsema.
Shape perception via a high-channel-count neuroprosthesis in monkey visual cortex.<\/a><\/strong>
Science 370(6521):1191-1196 (2020).<\/p>\n

J. Sorinas, M.D. Grima, J.M. Ferr\u00e1ndez, E. Fern\u00e1ndez.
Identifying Suitable Brain Regions and Trial Size Segmentation for Positive\/Negative Emotion Recognition.<\/a><\/strong>
Int. J. Neural Syst. 29(2):1850044 (2019).<\/p>\n

I. Gallego, I. Villate-Beitia, G. Mart\u00ednez-Navarrete, M. Men\u00e9ndez, T. L\u00f3pez-M\u00e9ndez, C. Soto-S\u00e1nchez, J. Z\u00e1rate, G. Puras, E. Fern\u00e1ndez, J.L. Pedraz.
Non-viral vectors based on cationic niosomes and minicircle DNA technology enhance gene delivery efficiency for biomedical applications in retinal disorders.<\/a><\/strong>
Nanomedicine 17:308-318 (2019).<\/p>\n

M. Mashal, N. Attia, G. Mart\u00ednez-Navarrete, C. Soto-S\u00e1nchez, E. Fern\u00e1ndez, Grijalvo S, R. Eritja, G. Puras, J.L. Pedraz.
Gene delivery to the rat retina by non-viral vectors based on chloroquine-containing cationic niosomes.<\/a><\/strong>
J. Control Release 304:181-190 (2019).<\/p>\n

A. Lozano, C. Soto-S\u00e1nchez, J. Garrig\u00f3s, J.J Mart\u00ednez, J.M: Ferr\u00e1ndez, E. Fern\u00e1ndez.
A 3D Convolutional Neural Network to Model Retinal Ganglion Cell\u2019s Responses to Light Patterns in Mice.<\/a><\/strong>
Int. J. Neural Syst. 28(10):1850043 (2018).<\/p>\n

M. Mashal, N. Attia, G. Puras, G. Mart\u00ednez-Navarrete, E. Fern\u00e1ndez, J.L. Pedraz.
Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60.<\/a><\/strong>
J. Control Release 254:55-64 (2017).<\/p>\n

M. Izquierdo-Serra, A. Bautista-Barrufet, A. Trapero, A. Garrido-Charles, A. D\u00edaz-Tahoces, N. Camarero, S. Pittolo, S. Valbuena, A. P\u00e9rez-Jim\u00e9nez, M. Gay, A. Garc\u00eda-Moll, C. Rodr\u00edguez-Escrich, J. Lerma, P. de la Villa, E. Fern\u00e1ndez, M.\u00c1. Peric\u00e0s, A. Llebaria, P. Gorostiza.
Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches.<\/a><\/strong>
Nat. Commun. 7:12221 (2016).<\/p>\n

J.M. Ayuso, M. Virumbrales-Mu\u00f1oz, A. Lacueva, P.M. Lanuza, E. Checa-Chavarria, P. Botella, E. Fern\u00e1ndez, M. Doblare, J.S. Allison, R.M. Phillips, J. Pardo, L.J. Fern\u00e1ndez, I. Ochoa.
Development and characterization of a microfluidic model of the tumour microenvironment.<\/a><\/strong>
Sci. Rep. 6:36086 (2016).<\/p>\n

 <\/p>\n

[\/et_pb_tab][et_pb_tab title=”Projects” _builder_version=”4.17.4″ body_font=”||||” body_line_height=”2em” tab_font=”||||” tab_line_height=”2em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” body_line_height_tablet=”2em” body_line_height_phone=”2em” tab_line_height_tablet=”2em” tab_line_height_phone=”2em” global_colors_info=”{}”]<\/p>\n

Neural Active Visual Prosthetics for Restoring Function (H2020). Funding agency: European Commission. Duration 2022 \u2013 2024
PI: Eduardo Fern\u00e1ndez Jover<\/em><\/p>\n

\n

Light-regulated drugs to restore sight (HR18-00501). Funding agency: Foundation La Caixa, Spain. Duration 2020 \u2013 2022
PI: Eduardo Fern\u00e1ndez Jover<\/em><\/p>\n

\n

European Network for integrated Training of innovative therapies for Vision Restoration (H2020). Funding agency: European Commission. Duration 2020 \u2013 2024
PI: Eduardo Fern\u00e1ndez Jover<\/em><\/p>\n

\n

Computational modeling framework for safety and efficacy assessment of PNS Stimulation (CNRS US-Spain research proposal). Funding agency: NSF (USA) and Ministry of Health, Spain. Duration 2018 \u2013 2022
PI: Eduardo Fern\u00e1ndez Jover<\/em><\/p>\n

\n

Innovative Neurotechnology for Society. Funding agency: Netherlands Organisation for Scientific Research. Duration 2020 \u2013 2027
PI: Eduardo Fern\u00e1ndez Jover<\/em>\u00a0<\/p>\n

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Responsable Fernando Fern\u00e1ndez L\u00e1zaro Web propia http:\/\/quimicaorganica.umh.es   RESUMEN DE LA INVESTIGACI\u00d3N Desde su descubrimiento, las perilendiimidas (PDI) han atra\u00eddo mucha atenci\u00f3n gracias a su fuerte absorci\u00f3n de la luz visible, sus elevados rendimientos cu\u00e1nticos de fluorescencia y su estabilidad t\u00e9rmica, qu\u00edmica y fotoqu\u00edmica. Otra vuelta de tuerca se produjo con la llegada de la […]<\/p>\n","protected":false},"author":1595,"featured_media":0,"parent":4231,"menu_order":57,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/8421"}],"collection":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/users\/1595"}],"replies":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/comments?post=8421"}],"version-history":[{"count":0,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/8421\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/pages\/4231"}],"wp:attachment":[{"href":"https:\/\/bioingenieria.umh.es\/en\/wp-json\/wp\/v2\/media?parent=8421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}